quot hiệu ứng cánh hoa quot petal effect và cơ chế vừa ghét nước vừa thích nước
Báo cáo y học: "The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanase" docx
... this effect is mediated by the selective inhibition of the activation of the p38 pathway and the downstream transcription factor cyclic-AMP responsive element binding protein (CREB) [23] This effect ... osteoarthritis osteoblasts Effects of cyclooxygenase and/or 5-lipoxygenase inhibition Arthritis Rheum 2002, 46:1804-1812 Huskisson EC, Berry H, Gishen P, Jubb RW, Whitehead J: Effects of antiinflammatory ... both concentrations reduced the levels of mRNA expression and protein synthesis of cathepsin K The effect was similar at both of the tested dosages for gene expression and more pronounced at the...
- 12
- 1,188
- 0
Senescence and Cell Cycle Control
... ataxia-telangiectasia mutated (ATM)/ATM and Rad3-related (ATR) kinases ROS can also upregulate p19ARF effectively in primary mouse cells Furthermore, the stress-responsive MAP kinase p38MAPK may play ... premature senescence in rat embryonic fibroblasts (Wu et al 2004) Seladin-1 may function as an ROS effector that facilitates p53 stabilization and consequently p21Cip1 induction In contrast to the ... Zebedee Z, Huot TJ, Stinson JA, Sugimoto M, Ohashi Y, Sharrocks AD, Peters G, Hara E (2001) Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence Nature 409:1067–1070...
- 14
- 347
- 0
Tài liệu Báo cáo khoa học: Inhibition of pneumococcal choline-binding proteins and cell growth by esters of bicyclic amines pptx
... observed (Fig 7A) The effect of ipratropium was again evident at lower concentrations than those needed for the atropine effect To gain a deeper insight into the physiologic effect of these compounds, ... compounds might also exert an inhibitory effect on the enzymatic activity of full-length cholinebinding murein hydrolases Figure 5A–C shows the inhibitory effect of choline, atropine, and ipratropium ... the bicyclic amines are also able to bind to the active site of Pce Effect of choline analogs on cell growth and viability Fig Effect of choline and analogs on the activity of cell wall lytic enzymes...
- 13
- 465
- 0
Báo cáo khoa học: The dipeptidyl peptidase IV family in cancer and cell biology pot
... lymphoblastic leukaemias and Effect? Protumorigenic or Anti-tumorigenic? Regulatory processes? Cell type? ECM environment? DPi Pro DP ligand Mechanism? Enzymatic, extraenzymatic? Effect of inhibitor? ... results may not accurately reflect the effect of DP inhibitors, which only inhibit enzymatic functions The gko mice could still be useful to prove that the effect of an inhibitor is DPIV or FAP ... similar effects have been found with both enzyme-inactive DP mutants and wild-type DP However, a change in expression level of a DP in response to a stimulus is likely to have downstream enzymatic effects;...
- 19
- 468
- 0
Understanding the participatory news consumer - How internet and cell phone users have turned news into a social experience pdf
... Finally, there are several other ways that people can customize their online news experiences In effect, they can create a kind of news “playlist” by using the internet to look at news events at ... high number of online news sites are more likely than others to have used news sites this way In effect, they are reallocating their attention to news to fit their own needs and schedule News creation, ... sample, one can say with 95% confidence that the error attributable to sampling and other random effects is plus or minus 2.3 percentage points For results based Internet users (n=1,675), the margin...
- 51
- 485
- 0
Báo cáo khoa học: Linking pseudouridine synthases to growth, development and cell competition potx
... the previously described dose effects of mfl alleles [18] As both phenotypic and molecular data indicated that the 46282 line exhibited the most marked silencing effect, this strain was used in ... To assess the specific effects on cell apoptosis, ap– GAL4,UAS–GFP silenced-discs were stained with antibody against activated Cas3 These experiments revealed a dramatic effect in late third instar ... allele were disadvantaged and did not survive, as a consequence of a cell competition-like effect Although this effect is thought to depend exclusively on the interaction of dyskerin with telomerase...
- 15
- 350
- 0
Báo cáo khoa học: Bridging the gap between in silico and cell-based analysis of the nuclear factor-jB signaling pathway by in vitro studies of IKK2 ppt
... model [10,37] to analyze in silico the effect of the parameter variation discussed above The parameter values chosen for this reaction have a signicant effect on the amplitude (but not the frequency) ... others [56,57] Effect of SC-514 Inhibitor on in silico nuclear NF-jB translocation To investigate whether the observed in vitro and cellbased inhibition data translated to an in silico effect, we ... changes in the experimental design had a profound effect on the kinetic data obtained Kinase assay environment was shown in this study to have a signicant effect on the Km,GST-IjBa, Km,ATP, and the...
- 13
- 475
- 0
Báo cáo khoa học: Inhibition of urokinase receptor gene expression and cell invasion by anti-uPAR DNAzymes in osteosarcoma cells pot
... antiproliferative effects To test whether the decreased number of cells on the Matrigel filters in the Dz720-treated wells is due to an anti-invasive effect rather than an antiproliferative effect, a ... additive or synergistic effect by using a combination of both active DNAzymes, northern blot analysis was performed as above We did not find any additive or synergistic effect using both Dz720 ... excess of Dz720, Dz483, and their mutants (data not shown) Effect of DNAzymes on uPAR mRNA reduction in Saos-2 cells To investigate the effects of Dz720 and Dz483 on uPAR mRNA changes, the DNAzymes...
- 11
- 315
- 0
Anatomy, Histology, and Cell Biology PreTestTM Self-Assessment and Review pptx
... use in corporate training programs For more information, please contact George Hoare, Special Sales, at george_hoare@mcgraw-hill.com or (212) 904-4069 TERMS OF USE This is a copyrighted work ... of cytokines by TH cells induces TC cells to proliferate and differentiate into effector cells In that case the effectors are cytotoxic T lymphocytes (CTLs) that recognize Class I MHC-antigen ... its surface, a naïve B cell proliferates to produce a memory B cell and a plasma cell that is the effector, synthesizing antibodies for release T cells are unable to recognize antigen on their own...
- 638
- 334
- 0
Targeting New Pathways and Cell Death in Breast Cancer Edited by Rebecca L. Aft docx
... biologically acted as antagonists Besides differences in biological effects of TPEs in MCF-7 cells and MCF-7:5C cells, biochemical effects of tested TPEs on ER complex similar to those with 4-OHT ... Kennedy, B J (1965) Systemic effects of androgenic and estrogenic hormones in advanced breast cancer J Am Geriatr Soc 13: 230-235 Kennedy, B J and I T Nathanson (1953) Effects of intensive sex steroid ... -10, and effector caspases, e.g caspases-3, -6 and -7 (Thornberry & Lazebnik, 1998) Initiator caspases processed and activated by upstream stimuli could cleave inactive proforms of effector caspases,...
- 190
- 414
- 0
Báo cáo khoa học: ERK and cell death: Mechanisms of ERK-induced cell death – apoptosis, autophagy and senescence doc
... cytochrome c, into the cytoplasm promotes the activation of initiator caspase-9, which in turn activates effector caspases such as caspase-3 or -7 The extrinsic pathway relies on the activation of death ... TNFRSF1A-associated via death domain (TRADD) ERK and cell death Strong caspase-8 activity may directly activate effector caspases; it may also require signal amplification through induction of the intrinsic pathway ... apoptosis ERK activity has been associated with classical markers of apoptosis execution, such as effector caspase-3 activation, poly(ADP-ribose) polymerase (PARP) cleavage, annexin-V staining,...
- 20
- 393
- 0
Báo cáo khoa học: ERK and cell death: ERK1⁄2 in neuronal death Srinivasa Subramaniam1 and Klaus Unsicker2 pptx
... from clear However, an understanding of the mechanisms of neuronal death is crucial for designing effective therapeutic strategies for neurodegenerative diseases Mitogen-activated protein kinase ... activity leads to neurite outgrowth and cell survival It has been proposed that this differential effect of ERK1 ⁄ may depend on the specific receptor availability It is well known that EGF receptors ... Similarly, inhibition of ERK1 ⁄ (MEK inhibitor, PD184352) to block proliferation has been shown to be effective in clinical trials in cancer patients [72] Therefore, understanding the detailed signaling...
- 8
- 311
- 0
Báo cáo khoa học: ERK and cell death: ERK location and T cell selection pdf
... the 34 plasma membrane mimics the effect of an ERK knockout and gives pJNK an unopposed opportunity or at least a head start in activating the proapoptotic effector molecules necessary for negative ... [51] Therefore, the sequestration of active ERK at the plasma membrane by negative selectors may effectively block the activation of these nucleus-resident transcription factors tipping the balance ... Smeyne R et al (2008) Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative 36 24 25 26 27 28 29 30 31 32 33 34 35 36 selection and prevents autoimmunity...
- 9
- 350
- 0
Báo cáo khoa học: ERK and cell death: cadmium toxicity, sustained ERK activation and cell death pot
... for cadmium entry Zinc is considered effective in protecting against cadmium poisoning [47] In our hands, although zinc has a significant, but somewhat modest, effect on the different cell types ... [51] However, it has been shown that the protective effect of PMA on cadmium is not due to its downregulation, but rather to a hit-and-run effect on PKC [22] Accordingly, when GF 109203X, a broad-spectrum ... cadmium toxicity, whereas blocking its activity has the opposite effect (Fig 2) [22] In short, PKC early activation has a protective effect on cadmium toxicity in HEK293 cells [22,49,53] It is intriguing...
- 8
- 368
- 0
Báo cáo khoa học: Activation of p21-activated kinase 1 is required for lysophosphatidic acid-induced focal adhesion kinase phosphorylation and cell motility in human melanoma A2058 cells potx
... corresponding vector transfectant However, PAK1 in the N19RhoAtransfected cells was still activated by LPA, indicating that Rac1 and Cdc42, but not RhoA, are located upstream of PAK1 during LPA-induced ... cells [35] and in rat ascite hepatoma cells [37] As RhoA was not required for LPA-induced PAK1 activation (Fig 2A and Fig 3), we examined the effects of PAK1 activation on LPA-induced FAK phosphorylation ... known to play an essential role in cell motility [29] and proliferation [30] In order to test the effects of LPA on PAK1 activity in A2058 human melanoma cells, serum starved cells were stimulated...
- 9
- 305
- 0
Báo cáo khoa học: PKA independent and cell type specific activation of the expression of caudal homeobox gene Cdx-2 by cyclic AM pptx
... seems that forskolin ⁄ IBMX has different effects on Cdx-2 promoter expression between endocrine cells and nonendocrine cells We then further examined the effect of forskolin ⁄ IBMX treatment for ... IBMX treatment generated no substantial effect on Cdx-2 mRNA expression in the Caco-2 cell line We then developed a real time RT-PCR approach to examine the effect of forskolin ⁄ IBMX on Cdx-2 mRNA ... First, we compared the effects of PKAc cotransfection on the expression of the Cdx-2 promoter vs the proglucagon gene promoter PKAc cotransfection generated no significant effect on Cdx-2 promoter...
- 14
- 506
- 0
schaum's easy outline molecular and cell biology - william stansfield, raul j cano, jaime s. colome
... use in corporate training programs For more information, please contact George Hoare, Special Sales, at george_hoare@mcgraw-hill.com or (212) 904-4069 TERMS OF USE This is a copyrighted work ... CHAPTER 1: Cells 17 and/or alcohol production is inhibited This phenomenon is known as the Pasteur effect Solved Problem 1.5 What occurs in meiosis, but not mitosis? Synapsis, crossing over, and...
- 129
- 273
- 0
apoptosis and cell proliferation
- 143
- 178
- 0
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008